Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Murietta belonged to a gang known as the Five Joaquins, who were notorious bandits during the height of the California Gold Rush. While Murietta's criminal activity likely did not have any political undertones, he nonetheless became a symbol of Mexican resistance as American settlers ventured to California. Unfortunately for him, this pushed the government to put a bounty on his head, leading to his murder and beheading. Luckily, Banderas's character didn't fall to the same fate.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Skeptics of climate change have long argued that global warming stopped around 1998, when an unusually powerful El Ni?o produced the hottest year of the 20th century. Some politicians in Washington have seized on that claim to justify inaction on emissions.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Trends and targets in antiviral phototherapy
This year they looked at the use of negative strategies such as anger or stonewalling responses to conflict, and found that these predicted health-related changes over time in specific ways.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Amid rising pollution and a strengthening yuan, the capital city saw its tourist numbers drop to 4.20 million visits from January to November from 5.01 million visits in 2012, according to China Daily, citing a report from China Tourism Academy and Beijing Commission of Tourism Development. An earlier report based on a survey of domestic travel agents showed that visitors to the capital declined by roughly 50% in the first three-quarters of the year compared with a year earlier.
宾夕法尼亚州立大学的气候科学家迈克尔·E·曼恩(Michael E. Mann)在电子邮件中说，“如果不是由于燃烧化石燃料所产生的、导致地球变暖的气体排放越来越多的原因，在上千年史无前例的几十年较暖期间、创纪录地变暖的十年中，看到变暖的又一个记录年度，是非常不可能的。”
ACE2 as a potential therapeutic target for pandemic COVID-19
The PPI fell 5.3 per cent year-on-year in January, moderating from December’s -5.9 per cent pace. PPI has remained in negative territory since March 2012, reaching a low of -5.9 per cent for the five consecutive months since August 2015.
Diagnostic technologies for COVID-19: a review
Gitanjali said she wanted to further refine the device so it could eventually go on the market.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
2. The 2012 Ig Nobel Peace Prize
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
A few recent scientific papers say that such long-lasting kinks in the jet stream have become more likely because global warming is rapidly melting the sea ice in the Arctic, but many leading scientists are not convinced on that point.
"Quality supervision authorities at all levels must intensify quality supervision and keep cracking down on law violations to improve the quality of products and protect consumers' rights," said Mei Kebao, deputy head of the administration.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Condos and co-ops have been laying down the law, writing warning memos and fining wayward residents. For renters, breaking the rules could jeopardize a lease. Condos are tightening security, asking doormen to scrutinize visitors and requiring residents to sign authorization forms for guests. The practice has also raised insurance concerns.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The drama and the original game have a large fan base and enjoy great popularity in China, and even elsewhere in Asia.
Antiviral drug discovery: broad-spectrum drugs from nature
Perhaps my favorite profile this year was Kiki Zhao’s stirring depiction of the remarkable Yu Xiuhua, now one of China’s most read poets, a woman with cerebral palsy who lived most of her 41 years on a farm, writing at a low table. She never finished high school, and says she “could write before she could read.” Now, she is invited to places like Stanford University and fends off comparisons to Emily Dickinson.
Her mother Stephanie Boyden, 32, says Bobbi is a 'diva' who runs to the stage when her name is called - and screams when she has to leave.
Influenza neuraminidase: A druggable target for natural products
In 2011, some seven years after the last season of Friends, over 36 million tuned into Comedy Central, a US satellite TV channel, to watch the show. The main demographic for this channel is 16 to 34 year olds, and viewing figures spiked during holidays, when extra episodes are also shown.
Warm greetings and best wishes for the New Year!致以热烈的祝贺和良好的祝福,新年快乐。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Britney, YOU drive me crazy for appearing on Loose Women smacking gum like it's 1998 as the panel interrogate you.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
1. Hundreds of genes spring to life after you die - and they keep functioning for up to four days. Together with an unexplained case in March that recorded brain activity in a corpse up to 10 minutes after death, we're starting to realise that death as we know it still retains some strange signs of life.
In the ranking of finance programmes for students already working in the industry, London Business School regains the top place it occupied between 2011 and 2015, while Judge Business School at Cambridge university drops back into second place.
Strong reviews, and praise for the performances - particularly from the children at the centre of the story, and Willem Dafoe, who plays the manager of the motel where they live.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Granted, it is easier to remake something than to make something new. Anyone who has faced a blank page knows that. But if fashion’s ubiquitous default to the 1960s over the last seven years has exposed anything, it is its own lack of imagination, not only about clothes and consumers, but about the relationship of culture and dress.
The upcoming launch will mark the five-year anniversary of the sinking of a South Korean warship in 2010, with the loss of 46 sailors. The South pinned the blame on the North and effectively froze all inter-Korean trade and investment ties.
Two years ago, the AFI delayed voting on its year-end list to give critics a chance to see Star Wars: The Force Awakens, which it subsequently included on its list of the 10 best films of 2015. However, this year, the latest Star Wars film, The Last Jedi, which hits theaters on Dec. 15, was nowhere to be found on AFI's list.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
“It’s horrible,” he said. “Whenever I see someone with a gun, I take it away and report it to police.”
Inhibition of SARS coronavirus helicase by bismuth complexes
泰勒·斯威夫特(Taylor Swift)，《空白空间》(Blank Space)， Big Machine
直到最近，Weill Cornell Medical College的科学家们至少在老鼠和猴子身上实现了这一点。这种人造视网膜，它的芯片可以将画面转换为电子信号，而它的微型投影机可以将电子信号转化为投影光线。
He failed to do so and Presti smartly moved on while he could still recoup some value.
On the a monthly basis prices fell by an average 0.5 per cent.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The EMBA ranking rates the best 100 programmes worldwide for working senior executives. The ranking is based on a survey of business schools as well as their students who graduated in 2012. The data measure how successful alumni have been in their career in terms of salary, seniority and achievements since graduating.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
"Another interesting aspect of this year's list is that more short numerical passwords showed up even though websites are starting to enforce stronger password policies."
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
An ancient Egyptian amulet was uncovered in Jerusalem by a young girl taking part in a family dig in the capital.
The film is shot to mark the tenth anniversary of the television series, first released in 2005.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Talented getaway driver Baby (Ansel Elgort) relies on the beat of his personal soundtrack to be the best in the game. After meeting the woman (Lily James) of his dreams, he sees a chance to ditch his shady lifestyle and make a clean break. Coerced into working for a crime boss (Kevin Spacey), Baby must face the music as a doomed heist threatens his life, love and freedom.
10. How to find IP address
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Taken together, these events and strategic initiatives highlight the Chinese aerospace industry’s realization that, in order to become a globally competitive player, it will need depth as much as breadth. After getting their hands on both ends of the value chain—aircraft design and final assembly—the Chinese now understand that what will make or break their industry over the long term is what happens in the middle of the value chain, at the component and subsystem levels. And that is why China’s ambition to compete with Boeing and Airbus, as well as with GE and Rolls-Royce for aircraft engines, is now more credible than ever.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The potential impact of any surprise move in Fed policy was clear in the “taper tantrum” of 2013, when just the suggestion that the Fed might soon rein in its ultra-loose monetary policies was enough to provoke a wave of global panic.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
而传统主义者诸如乔治·克鲁尼（George Clooney），他因影片《逃离德黑兰》（Argo）获最佳影片奖以及在影片《辛瑞那》（Syriana ）中获最佳男配角，他的奥斯卡奖杯放在家中的书房。达斯汀·霍夫曼（Dustin Hoffman）曾在1980年因影片《克莱默夫妇》（Kramer vs. Kramer） 、并在九年后因影片《雨人》（Rain Man）两次获最佳男主角奖，也将其奖杯放在书房中。
Extreme heat blanketed Alaska and much of the western United States last year. Records were set across large areas of every inhabited continent. And the ocean surface was unusually warm virtually everywhere except near Antarctica, the scientists said, providing the energy that fueled damaging Pacific storms.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
History will look back on 2012 as the year when China anointed its "fifth generation" of leaders and shifted to a slower growth trajectory, writes Yukon Huang. This transition will take place against a backdrop of daunting internal challenges — increasing social unrest, widening income disparities and both ecological and man-made disasters — and of escalating external tensions, stemming from America's "pivot" to Asia and simmering regional worries about China's economic rise.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
9. Jessica Pare
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Payne, a former lottery pick, missed time with a foot injury and hasn't shown any major progress as a shooter or a defender in year two.
As for the fortunes of the gig economy, the UK will be a key country to watch. The government is due to respond to an independent review into whether British law is keeping up with this new trend. Bold policy action — either in favour or against online labour platforms — now seems less likely given the fragility of the government and the time-consuming nature of Brexit.
The letter read: “The BFC shouldn't be endorsing a material whose production is deemed so cruel that it is outlawed in the UK.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
8. 茱莉亚-罗伯茨 1200万美元
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
All told, Ujiri parted with Terrence Ross, Jared Sullinger, and a total of three picks to acquire the two veterans.
Premiered on Jan 29, the drama received 7 points out of 10 on the country's popular review website Douban.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
In 2008, Janah talked to a call center worker from Dharavi, India, the largest slum in South Asia, while working as a consultant. The worker said there were millions of unemployed villagers as talented as he was. "I thought, 'What if outsourcing could generate a few dollars for billions of people, rather than billions of dollars for a wealthy few'" Janah says. She went on to launch Samasource, a tech platform that connects impoverished women and youth with large corporations like Google, LinkedIn, and Microsoft to complete digital projects. To date, the non-profit has helped over 16,000 people rise above the poverty line and it recently launched SamaUSA, a domestic program for low-income students living in San Francisco.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
New residential property prices in China grew faster in October despite a slew of restrictions on purchases,
Moonlight, an evocative coming of age story about a young gay black man, won best picture at the 2017 Oscars but was almost denied its victory in chaotic scenes when the award was mistakenly given to La La Land.
"Hard to believe so many doctors lied in the papers. Can patients still trust them to help us treat diseases?" wrote one Sina Weibo user.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Audrey Zhang, a fifth-grader from Levittown, N.Y., is the winner of this year's Doodle 4 Google competition, rising to the top of some 100,000 entries on the theme of "draw one thing to make the world a better place."
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
With interest rates expected to rise only slowly, commodities are likely to attract hedge funds and other speculative investors looking for juicier returns, said the bank.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
He took out his textbooks and busied himself with his daily homework routine.
Someone might tell you to ‘Be yourself' in the interview. Don't be yourself. That's the worst advice ever. We don't want people who are neurotic and quirky and whatever else. All we care about is your skill and experience.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
毕竟，在最新一批时装系列中，最引人注目的系列有流线形的趋势，没有被任何与60年代有关的元素或身份拖住——例如，路易威登(Louis Vuitton)、迪奥(Dior)、普罗恩萨·施罗(Proenza Schouler)和纳西索·罗德里格斯(Narciso Rodriguez)——这些服装大踏步走向未来，没有往昔的负累。
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
adj. 确实的，保障的，有自信的 动词assure的过
A facile assay for rapid detection of COVID-19 antibodies
When scientists discover how to shrink humans to five inches tall as a solution to overpopulation, Paul (Matt Damon) and his wife Audrey (Kristen Wiig) decide to abandon their stressed lives in order to get small and move to a new downsized community, a choice that triggers life-changing adventures.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The programme entered the ranking in second place in 2006 and was ranked top in 2008.
'People go crazy and it gets overwhelming.'
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
vt. 作 ... 姿
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Cross talk “Wishes From All Over China” (A group of performers)
The total amount of remittances, which is estimated to reach $450 billion in 2017, has risen by more than 50 percent in the past decade, IFAD said.
Targeted poverty alleviation
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The media are annoying, we get that, Your Royal Highness, but there may have been more dignified ways for you (and the establishment you represent) to air your concerns.
The application window will close on Saturday, and successful candidates must pass the 2016 national civil service exam, which starts on Nov 29, before they're granted a job interview in March.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Over the past three years, drawing conclusions about China's box office growth has been complicated by Beijing's decision to include new service fees in official revenue totals.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The 2018 Academic Ranking of World Universities released last Wednesday by Shanghai Ranking Consultancy reveals that 62 research universities in China have made their list of the world's top 500 universities.
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
4. OPEC’s Next Move.OPEC deserves a lot of credit (or blame) for the remarkable downturn in oil prices last year.While many pundits have declared OPEC irrelevant after their decision to leave output unchanged, the mere fact that oil prices crashed after the cartel’s November meeting demonstrates just how influential they are over price swings. For now OPEC – or, more accurately, Saudi Arabia – has stood firm in its insistence not to cut production quotas. Whether that remains true through 2015 is up in the air.
We will strengthen our capability for making technological innovations.
The GDP of Southwest China's Chongqing Municipality grew by 10.7 percent in 2016, hitting 1.76 trillion yuan. Southwest China's Guizhou province and Tibet autonomous region posted 10.5 percent and 10 percent growth respectively.
*Writing for a Variety Series: “Last Week Tonight With John Oliver”
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
If Lloyd Grossman were to go through the keyholes of Oscar winners’ houses, he would find their golden statues in various spots: from prime real estate such as the mantelpiece to the depths of cupboards collecting dust.
The collaboration with business is important, adds Teach First, not just for the funding but to help schools equip students with more of the skills required by modern employers.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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